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Ion channel regulation by phosphoinositides analyzed with VSPs – PI(4,5)P2 affinity, phosphoinositide selectivity, and PI(4,5)P2 pool accessibility

The activity of many proteins depends on the phosphoinositide (PI) content of the membrane. E.g., dynamic changes of the concentration of PI(4,5)P2 are cellular signals that regulate ion channels. The susceptibility of a channel to such dynamics depends on its affinity for PI(4,5)P2. Yet, measuring...

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Principais autores: Alexandra eRjasanow, Michael G. Leitner, Veronika eThallmair, Christian R Halaszovich, Dominik eOliver
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015-06-01
Serier:Frontiers in Pharmacology
Fag:
potassium channel
5)P2
microdomain
phosphoinositide
Ci-VSP
Lipid phosphatase
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00127/full
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