A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism.
Synthetic Lethality (SL) is currently defined as a type of genetic interaction in which the loss of function of either of two genes individually has limited effect in cell viability but inactivation of both genes simultaneously leads to cell death. Given the profound genomic aberrations acquired by...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2022-03-01
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| Serie: | PLoS Computational Biology |
| Accesso online: | https://doi.org/10.1371/journal.pcbi.1009395 |
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