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Associated uncertainty estimation during the validation process of TCID50 and FRNT neutralization assays against SARS-CoV-2 variants, used in population surveillance research and correlates of protection

Neutralizing antibody (nAb) assays are essential for evaluating antibody-mediated immune response against SARS-CoV-2, in the context of efficacy and potency of vaccines, as well as population-level surveillance. This study aimed to estimate the associated uncertainty during the validation of two neu...

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Principais autores: Edgar Reyna-Rosas, Milton Nieto-Ponce, Andrea Palencia-Reyes, Carlos Blancas-Ruíz, Claudia Carranza, Martha Torres, Horacio Zamudio-Meza
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-03-01
coleção:Frontiers in Immunology
Assuntos:
correlates of protection against SARS-CoV-2
FRNT
method validation
TCID50MN
uncertainty estimation
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1768395/full
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