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Effects of miR-204-5p modulation on PAX6 regulation and corneal inflammation

Abstract Congenital aniridia is a rare eye disease characterized by loss of PAX6 protein leading to aniridia-associated keratopathy that significantly reduces vision. The miR-204-5p is a possible regulator of PAX6 function and here we evaluate its effect in multiple in vitro and in vivo models. In v...

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Principais autores: Mojdeh Abbasi, Maryam Amini, Petros Moustardas, Quirin Gutsmiedl, Dina Javidjam, Shweta Suiwal, Berthold Seitz, Fabian N. Fries, Ava Dashti, Yedizza Rautavaara, Tanja Stachon, Nóra Szentmáry, Neil Lagali
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-11-01
Serier:Scientific Reports
Fag:
Aniridia
MiR-204-5p
PAX6
Keratitis
Corneal inflammation
Online adgang:https://doi.org/10.1038/s41598-024-76654-w
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