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Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates.

The filoviruses, Marburg virus and Ebola virus, cause severe hemorrhagic fever with high mortality in humans and nonhuman primates. Among the most promising filovirus vaccines under development is a system based on recombinant vesicular stomatitis virus (rVSV) that expresses an individual filovirus...

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Autors principals: Chad E Mire, Andrew D Miller, Angela Carville, Susan V Westmoreland, Joan B Geisbert, Keith G Mansfield, Heinz Feldmann, Lisa E Hensley, Thomas W Geisbert
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2012-01-01
Col·lecció:PLoS Neglected Tropical Diseases
Accés en línia:http://europepmc.org/articles/PMC3308941?pdf=render
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