Baseline and early changes in eosinophil count and neutrophil-to-eosinophil ratio predict outcomes in metastatic renal cell carcinoma treated with nivolumab

Abstract The role of eosinophils in patients with cancer receiving systemic therapy based on immune checkpoint inhibitors (ICIs) has become a subject of increasing interest. The aim of the present study was to assess the prognostic role of absolute eosinophil count (AEC) and neutrophil-to-eosinophil...

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Hauptverfasser:	Ondřej Fiala, Katarína Rejleková, Tomas Buchler, Hana Študentová, Alexandr Poprach, Michal Vočka, Petr Hošek, Jindřich Kopecký, Martin Matějů, Anežka Zemánková, Martina Spisarová, Michaela Tkadlecová, Peter Priester, Jan Kouřil, Radka Lohynská, Lucie Grmelová, Alexander Savka, Katarína Štefániková, Jana Obertová, Dominika Šiková, Petr Stránský, Bohuslav Melichar, Patrik Palacka
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-12-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Renal cell carcinoma Eosinophils Neutrophil-to-eosinophil ratio Immunotherapy Nivolumab
Online-Zugang:	https://doi.org/10.1038/s41598-025-32593-8
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