Ligand-based targeting of c-kit using engineered γδ T cells as a strategy for treating acute myeloid leukemia

The application of immunotherapies such as chimeric antigen receptor (CAR) T therapy or bi-specific T cell engager (BiTE) therapy to manage myeloid malignancies has proven more challenging than for B-cell malignancies. This is attributed to a shortage of leukemia-specific cell-surface antigens that...

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Үндсэн зохиолчид:	Gianna M. Branella, Jasmine Y. Lee, Jennifer Okalova, Kiran K. Parwani, Jordan S. Alexander, Raquel F. Arthuzo, Andrew Fedanov, Bing Yu, David McCarty, Harrison C. Brown, Shanmuganathan Chandrakasan, Brian G. Petrich, Christopher B. Doering, H. Trent Spencer
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2023-11-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	acute myeloid leukemia (AML) gamma delta (γδ) T cells ligand-based therapeutics chimeric antigen receptor (CAR) secreted bispecific T cell engager stem cell factor (SCF)
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1294555/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!