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The Tissue Distribution of SARS-CoV-2 in Transgenic Mice With Inducible Ubiquitous Expression of hACE2

The novel coronavirus disease COVID-19 has become one of the most socially significant infections. One of the main models for COVID-19 pathogenesis study and anti-COVID-19 drug development is laboratory animals sensitive to the virus. Herein, we report SARS-CoV-2 infection in novel transgenic mice c...

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Gespeichert in:
Hauptverfasser: Alexander A. Dolskiy, Andrey S. Gudymo, Oleg S. Taranov, Irina V. Grishchenko, Ekaterina M. Shitik, Dmitry Yu Prokopov, Vladislav O. Soldatov, Elvira V. Sobolevskaya, Sergey A. Bodnev, Natalia V. Danilchenko, Anastasia A. Moiseeva, Polina Y. Torzhkova, Yulia A. Bulanovich, Galina S. Onhonova, Elena K. Ivleva, Marina V. Kubekina, Andrey E. Belykh, Tatiana V. Tregubchak, Alexander B. Ryzhikov, Elena V. Gavrilova, Rinat A. Maksyutov, Alexey V. Deykin, Dmitry V. Yudkin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2022-01-01
Schriftenreihe:Frontiers in Molecular Biosciences
Schlagworte:
SARS-CoV-2
intranasal infection
transgenic mice
hACE2 switch-on mice
ACE2
Cre recombinase
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fmolb.2021.821506/full
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