The Synaptic Clock: SynGAP1 as a Molecular Timer of Postsynaptic Density Consolidation

<i>SYNGAP1</i>-related intellectual disability presents a therapeutic paradox where genetic rescue is highly effective in neonates but limited in adults, suggesting that deficiency represents a developmental trajectory violation rather than a static biochemical defect. By synthesizing molecular, bio...

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Bibliographic Details

Main Authors:	Zixuan Cao, Yibin Jia, Zhuoyuan Zhang, Hanjiang Xue, Hanwei Yu, Xin Li, Peng Luo
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2026-06-01
Series:	Biomolecules
Subjects:	SynGAP1 liquid–liquid phase separation critical period gene therapy postsynaptic density isoform switching
Online Access:	https://www.mdpi.com/2218-273X/16/6/876
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