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Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons

Summary: Pre-clinical studies of fragile X syndrome (FXS) have focused on neurons, with the role of glia remaining largely underexplored. We examined the astrocytic regulation of aberrant firing of FXS neurons derived from human pluripotent stem cells. Human FXS cortical neurons, co-cultured with hu...

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Auteurs principaux: Shreya Das Sharma, Bharath Kumar Reddy, Rakhi Pal, Tuula E. Ritakari, James D. Cooper, Bhuvaneish T. Selvaraj, Peter C. Kind, Siddharthan Chandran, David J.A. Wyllie, Sumantra Chattarji
Format: Artigo
Langue:Inglês
Publié: Elsevier 2023-04-01
Collection:Cell Reports
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Accès en ligne:http://www.sciencedirect.com/science/article/pii/S2211124723003558
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