The medial orbitofrontal cortex mediates neuropathic pain and anxiodepressive-like behaviors via two distinct pathways

Abstract Background Chronic neuropathic pain is frequently accompanied by anxiety and depression, yet the cortical circuit mechanisms underlying this comorbidity remain unclear. The medial orbitofrontal cortex (mOFC) is a key cortical region involved in emotional regulation and valuation, and clinic...

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Detalhes bibliográficos

Principais autores:	Zhixiao Li, Tianen Si, Liangliang Gao, Yijie Meng, Xinyu Su, Liang Tao, Jingjing Zhang, Zhonghui Hu, Yao Ge, Xianglei Meng, Jing Cao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-03-01
coleção:	The Journal of Headache and Pain
Assuntos:	Neuropathic pain Medial orbitofrontal cortex (mOFC) Anxiety and depression Basolateral amygdala (BLA) Mediodorsal thalamus (MD)
Acesso em linha:	https://doi.org/10.1186/s10194-026-02335-w
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