JPH203, a newly developed anti-cancer drug, shows a preincubation inhibitory effect on L-type amino acid transporter 1 function

JPH203 is a novel anti-cancer drug targeting L-type amino acid transporter 1 (LAT1), which plays a primary role in the uptake of essential amino acids in tumor cells. Although a co-incubation inhibitory effect of JPH203 has been shown in a conventional uptake assay, its preincubation inhibitory effe...

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Principais autores:	Kentaro Okunushi, Tomomi Furihata, Hanae Morio, Yasuhide Muto, Kosuke Higuchi, Meika Kaneko, Yusuke Otsuka, Yuta Ohno, Yasuhiro Watanabe, Yoshie Reien, Kiyoshi Nakagawa, Shinichi Sakamoto, Hidefumi Wakashin, Naoki Shimojo, Naohiko Anzai
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2020-09-01
Series:	Journal of Pharmacological Sciences
Assuntos:	LAT1 JPH203 Preincubation inhibitory effects Anti-cancer drug Amino acid transporter
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S1347861320300633
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