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Multi-Omics Analysis of Glioblastoma and Glioblastoma Cell Line: Molecular Insights Into the Functional Role of GPR56 and TG2 in Mesenchymal Transition

G protein-coupled receptor 56 (GPR56/ADGRG1) is an adhesion GPCR with an essential role in brain development and cancer. Elevated expression of GPR56 was observed in the clinical specimens of Glioblastoma (GBM), a highly invasive primary brain tumor. However, we found the expression to be variable a...

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Principais autores: Raksha A. Ganesh, Pranali Sonpatki, Divya Naik, Arivusudar Everad John, Gajanan Sathe, Akhila Lakshmikantha, Komal Prasad Chandrachari, Lea Bauer, Vera Knäuper, Daniel Aeschlimann, Krishnan Venkatraaman, Nameeta Shah, Ravi Sirdeshmukh
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-05-01
Serier:Frontiers in Oncology
Fag:
GPR56/ADGRG1
TG2
mesenchymal transition
GBM - glioblastoma multiforme
omics analysis
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2022.841890/full
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