Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy

Abstract Background Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Infiltration and alterations in non-cardiomyocytes of the human heart involve crucially in the occurrence of DCM and associated immunotherapeutic approaches. Methods We constructed a single-cell trans...

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Hauptverfasser:	Siyu He, Chunyu Li, Mingxin Lu, Fang Lin, Sangyu Hu, Junfang Zhang, Luying Peng, Li Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-01-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	Dilated cardiomyopathy (DCM) Single-cell RNA sequencing (scRNA-seq) Bulk RNA sequencing (Bulk RNA-seq) Non-cardiomyocytes Heterogeneity
Online-Zugang:	https://doi.org/10.1186/s12967-024-05983-1
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