USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling

Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and targeting ALK3 for ubiquitin-mediated degradation...

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Bibliografske podrobnosti

Principais autores:	Lina Herhaus, Mazin A. Al-Salihi, Kevin S. Dingwell, Timothy D. Cummins, Lize Wasmus, Janis Vogt, Richard Ewan, David Bruce, Thomas Macartney, Simone Weidlich, James C. Smith, Gopal P. Sapkota
Format:	Artigo
Jezik:	Inglês
Izdano:	The Royal Society 2014-01-01
Serija:	Open Biology
Teme:	bone morphogenetic protein deubiquitylation usp15 ubiquitin alk3 smad
Online dostop:	https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140065
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