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Changes of PK/PD of Meropenem in patients with abdominal septic shock and exploration of clinical rational administration plan: a prospective exploratory study

Abstract This study aimed to explore the changes of pharmacokinetic parameters after meropenem in patients with abdominal septic shock after gastrointestinal perforation, and to simulate the probability of different dosing regimens achieving different pharmacodynamic goals. The study included 12 pat...

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Principais autores: Youquan Wang, Hongxiang Li, Dongxia Wang, Yuting Li, Yangyang Shen, Yao Fu, Yanhua Li, Meng Gao, Dong Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-05-01
Serier:Scientific Reports
Fag:
Meropenem
Pharmacokinetics/pharmacodynamics
Septic shock
Monte Carlo simulation
Intensive care
Online adgang:https://doi.org/10.1038/s41598-024-60909-7
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