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Sex differences and risk factors for bleeding in Alagille syndrome

Abstract Spontaneous bleeds are a leading cause of death in the pediatric JAG1‐related liver disease Alagille syndrome (ALGS). We asked whether there are sex differences in bleeding events in patients, whether Jag1Ndr/Ndr mice display bleeds or vascular defects, and whether discovered vascular patho...

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Principais autores: Simona Hankeova, Noemi Van Hul, Jakub Laznovsky, Elisabeth Verboven, Katrin Mangold, Naomi Hensens, Csaba Adori, Elvira Verhoef, Tomas Zikmund, Feven Dawit, Michaela Kavkova, Jakub Salplachta, Marika Sjöqvist, Bengt R Johansson, Mohamed G Hassan, Linda Fredriksson, Karsten Baumgärtel, Vitezslav Bryja, Urban Lendahl, Andrew Jheon, Florian Alten, Kristina Teär Fahnehjelm, Björn Fischler, Jozef Kaiser, Emma R Andersson
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Nature 2022-11-01
coleção:EMBO Molecular Medicine
Assuntos:
Alagille syndrome
Bleeding
Jagged1
Notch
Vasculature
Acesso em linha:https://doi.org/10.15252/emmm.202215809
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