Traceless cysteine-linchpin enables precision engineering of lysine in native proteins
Controlling the selectivity of the chemical modification of a genetic-manipulation-free protein is currently problematic. Here the authors report a method using cysteine-based chemoselective Linchpin Directed site-selective Modification of the lysine residue in a protein.
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| Principais autores: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2022-10-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-022-33772-1 |
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