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Traceless cysteine-linchpin enables precision engineering of lysine in native proteins

Controlling the selectivity of the chemical modification of a genetic-manipulation-free protein is currently problematic. Here the authors report a method using cysteine-based chemoselective Linchpin Directed site-selective Modification of the lysine residue in a protein.

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Bibliografiske detaljer
Principais autores: Neelesh C. Reddy, Rajib Molla, Pralhad Namdev Joshi, Sajeev T. K., Ipsita Basu, Jyotsna Kawadkar, Neetu Kalra, Ram Kumar Mishra, Suman Chakrabarty, Sanjeev Shukla, Vishal Rai
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2022-10-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/s41467-022-33772-1
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