Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel NaV1.7

The voltage-gated sodium (NaV) channel subtype NaV1.7 plays a critical role in pain signaling, making it an important drug target. Here we studied the molecular interactions between μ-Conotoxin KIIIA (KIIIA) and the human NaV1.7 channel (hNaV1.7). We developed a structural model of hNaV1.7 using Ros...

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Hlavní autoři:	Ian H. Kimball, Phuong T. Nguyen, Baldomero M. Olivera, Jon T. Sack, Vladimir Yarov-Yarovoy
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-03-01
Edice:	Frontiers in Pharmacology
Témata:	voltage-gated sodium (NaV) channels conotoxins NaV1.7 channel Rosetta software protein-protein interaction (PPI)
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1156855/full
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