PureCLIP: capturing target-specific protein–RNA interaction footprints from single-nucleotide CLIP-seq data

Abstract The iCLIP and eCLIP techniques facilitate the detection of protein–RNA interaction sites at high resolution, based on diagnostic events at crosslink sites. However, previous methods do not explicitly model the specifics of iCLIP and eCLIP truncation patterns and possible biases. We develope...

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Detalles Bibliográficos

Principais autores:	Sabrina Krakau, Hugues Richard, Annalisa Marsico
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2017-12-01
Series:	Genome Biology
Assuntos:	Protein–RNA interaction iCLIP-seq eCLIP-seq Crosslink sites Hidden Markov model
Acceso en liña:	http://link.springer.com/article/10.1186/s13059-017-1364-2
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