Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

Human cytomegalovirus (HCMV) infects up to 80% of the world’s population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 hr after infection. Integrative analyses reveal HC...

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Autors principals:	Khund Sayeed, Sreeja Parameswaran, Matthew J Beucler, Lee E Edsall, Andrew VonHandorf, Audrey Crowther, Omer A Donmez, Matthew R Hass, Scott Richards, Carmy R Forney, Hayley K Hesse, Sydney H Jones, Katelyn A Dunn, Jay Wright, Merrin Man Long Leong, Laura A Murray-Nerger, Vijay Yechoor, Ben E Gewurz, Kenneth M Kaufman, John B Harley, Bo Zhao, William E Miller, Leah C Kottyan, Matthew T Weirauch
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2025-09-01
Col·lecció:	eLife
Matèries:	gene regulation functional genomics virus infection cytomegalovirus epigenetics
Accés en línia:	https://elifesciences.org/articles/101578
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