Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q

Summary: Background: Haploinsufficiency (HI) resulting from deletion of the long arm of chromosome 5 [del(5q)] and the accompanied loss of heterozygosity are likely key pathogenic factors in del(5q) myeloid neoplasia (MN) although the consequences of del(5q) have not been yet clarified. Methods: He...

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Principais autores:	Vera Adema, Laura Palomo, Wencke Walter, Mar Mallo, Stephan Hutter, Thomas La Framboise, Leonor Arenillas, Manja Meggendorfer, Tomas Radivoyevitch, Blanca Xicoy, Andrea Pellagatti, Claudia Haferlach, Jacqueline Boultwood, Wolfgang Kern, Valeria Visconte, Mikkael Sekeres, John Barnard, Torsten Haferlach, Francesc Solé, Jaroslaw P. Maciejewski
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2022-06-01
Series:	EBioMedicine
Assuntos:	Myelodysplastic syndromes 5q deletion Haploinsufficiency TP53 CSNK1A1
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2352396422002407
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