Senescence and Inflamm-Aging Are Associated With Endothelial Dysfunction in Men But Not Women With Atherosclerosis

Summary: Coronary artery disease (CAD) is more prevalent in men than in women, with endothelial dysfunction, prodromal to CAD, developing a decade earlier in middle-aged men. We investigated the molecular basis of this dimorphism ex vivo in arterial segments discarded during surgery of CAD patients....

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Autors principals:	Pauline Mury, PhD, Gael Cagnone, PhD, Olina Dagher, MD, Florian Wünnemann, PhD, Guillaume Voghel, MD, PhD, Melissa Beaudoin, MSc, Mélanie Lambert, PhD, Géraldine Miquel, BSc, Pierre-Emmanuel Noly, MD, PhD, Louis P. Perrault, MD, PhD, Michel Carrier, MD, Nathalie Thorin-Trescases, PhD, Jean-Sébastien Joyal, MD, PhD, Guillaume Lettre, PhD, Eric Thorin, PhD
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-10-01
Col·lecció:	JACC: Basic to Translational Science
Matèries:	coronary artery disease endothelium-dependent relaxation inflammaging sex-dimorphism
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2452302X24002596
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