2-Amido-3-(1H-Indol-3-yl)-N-Substitued-Propanamides as a New Class of Falcipain-2 Inhibitors. 1. Design, Synthesis, Biological Evaluation and Binding Model Studies

The Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is an important cysteine protease and an essential hemoglobinase of erythrocytic P. falciparum trophozoites. The discovery of new FP-2 inhibitors is now a hot topic in the search for potential malaria treatments. In this study, a series...

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Detaylı Bibliyografya

Asıl Yazarlar:	Tong Chen, Jin Zhu, Peng Che, Lili Chen, Weiqiang Lu, Jin Huang, Jian Li, Honglin Li, Hualiang Jiang
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	MDPI AG 2009-01-01
Seri Bilgileri:	Molecules
Konular:	3-(1H-Indol-3-yl)-propanamide derivatives Falcipain-2 inhibitor Malaria SAR
Online Erişim:	http://www.mdpi.com/1420-3049/14/1/494/
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