Inhibition of choline metabolism in an angioimmunoblastic T-cell lymphoma preclinical model reveals a new metabolic vulnerability as possible target for treatment

Abstract Background Angioimmunoblastic T-cell lymphoma (AITL) is a malignancy with very poor survival outcome, in urgent need of more specific therapeutic strategies. The drivers of malignancy in this disease are CD4+ follicular helper T cells (Tfh). The metabolism of these malignant Tfh cells was n...

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Principais autores:	Adrien Krug, Marie Tosolini, Blandine Madji Hounoum, Jean-Jacques Fournié, Roger Geiger, Matteo Pecoraro, Patrick Emond, Philippe Gaulard, François Lemonnier, Jean-Ehrland Ricci, Els Verhoeyen
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2024-02-01
Serija:	Journal of Experimental & Clinical Cancer Research
Teme:	Choline AITL Lipid metabolism CDP-choline pathway CDP-ethanolamine pathway Choline kinase
Online dostop:	https://doi.org/10.1186/s13046-024-02952-w
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