Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density

GWAS have identified numerous genetic loci for bone mineral density (BMD) and fracture risk. Here, the authors map these variants to putative target genes using ATAC-seq and Capture C of human osteoblasts and confirm ING3 and EPDR1 as BMD genes in in vitro osteoblast differentiation experiments.

Detalhes bibliográficos

Principais autores:	Alessandra Chesi, Yadav Wagley, Matthew E. Johnson, Elisabetta Manduchi, Chun Su, Sumei Lu, Michelle E. Leonard, Kenyaita M. Hodge, James A. Pippin, Kurt D. Hankenson, Andrew D. Wells, Struan F. A. Grant
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2019-03-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-019-09302-x
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