Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1

In eukaryotic cells, inefficient splicing is surprisingly common and leads to the degradation of transcripts with retained introns. How pre-mRNAs are committed to nuclear decay is unknown. Here, we uncover a mechanism by which specific intron-containing transcripts are targeted for nuclear degradati...

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Detalhes bibliográficos

Principais autores:	Cornelia Kilchert, Sina Wittmann, Monica Passoni, Sneha Shah, Sander Granneman, Lidia Vasiljeva
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2015-12-01
coleção:	Cell Reports
Assuntos:	splicing mRNA Mmi1 RNA exosome RNA decay intron retention
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124715013261
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