A CD64/FcγRI-mediated mechanism hijacks PD-1 from PD-L1/2 interaction and enhances anti-PD-1 functional recovery of exhausted T cells

Therapeutic monoclonal antibodies (mAb) targeting the immune checkpoint inhibitor programmed cell death protein 1 (PD-1) have achieved considerable clinical success in anti-cancer therapy through relieving T cell exhaustion. Blockade of PD-1 interaction with its ligands PD-L1 and PD-L2 is an importa...

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Autors principals:	Victor Joo, Constantinos Petrovas, Laurence de Leval, Alessandra Noto, Michel Obeid, Craig Fenwick, Giuseppe Pantaleo
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-08-01
Col·lecció:	Frontiers in Immunology
Matèries:	PD1 (programmed cell death protein 1) immunotherapy internalization FcγRI(CD64) T cell mAb
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213375/full
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