SIRT3 elicited an anti‐Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis

Abstract Cholangiocarcinoma (CCA) is an extremely invasive malignancy with late diagnosis and unfavorable prognosis. Surgery and chemotherapy are still not effective in improving outcomes in CCA patients. It is crucial to explore a novel therapeutic target for treating CCA. An NAD‐dependent deacetyl...

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Hauptverfasser:	Lei Xu, Yang Li, Lixing Zhou, Robert Gregory Dorfman, Li Liu, Rui Cai, Chenfei Jiang, Dehua Tang, Yuming Wang, Xiaoping Zou, Lei Wang, Mingming Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2019-05-01
Schriftenreihe:	Cancer Medicine
Schlagworte:	Cholangiocarcinoma Metabolic reprogramming SIRT3 Warburg effect
Online-Zugang:	https://doi.org/10.1002/cam4.2089
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