γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43

Deciphering the mechanism by which the relative Aβ42(43) to total Aβ ratio is regulated is central to understanding Alzheimer disease (AD) etiology; however, the mechanisms underlying changes in the Aβ42(43) ratio caused by familial mutations and γ-secretase modulators (GSMs) are unclear. Here, we s...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Masayasu Okochi, Shinji Tagami, Kanta Yanagida, Mako Takami, Takashi S. Kodama, Kohji Mori, Taisuke Nakayama, Yasuo Ihara, Masatoshi Takeda
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2013-01-01
coleção:	Cell Reports
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124712004305
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!