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MHCquant2 refines immunopeptidomics tumor antigen discovery

Abstract Confident identification of human leukocyte antigen (HLA)-presented peptides is crucial for advancing cancer immunotherapy. We present MHCquant2, a scalable and modular Nextflow pipeline integrated into nf-core as a reproducible, portable, and standardized workflow for immunopeptidomics. Th...

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Sábháilte in:
Príomhchruthaitheoirí: Jonas Scheid, Steffen Lemke, Naomi Hoenisch-Gravel, Anna Dengler, Timo Sachsenberg, Arthur Declerq, Ralf Gabriels, Jens Bauer, Marcel Wacker, Leon Bichmann, Lennart Martens, Marissa L. Dubbelaar, Sven Nahnsen, Juliane S. Walz
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: BMC 2025-09-01
Sraith:Genome Biology
Ábhair:
Immunopeptidomics
Nextflow
Nf-core
Pipeline
Mass spectrometry
HLA
Rochtain ar líne:https://doi.org/10.1186/s13059-025-03763-8
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