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Longitudinal MRI-based changes in intracranial volume and skull thickness observed in both metachromatic leukodystrophy and multiple sclerosis

Intracranial volume (ICV) is often used as normalization factor in volumetrics and considered to be stable in young adults. We noticed thick skulls on MRI scans of leukodystrophy patients, suggesting potentially changing skull morphology. In this study we aimed to quantify skull thickness and ICV in...

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Wedi'i Gadw mewn:
Prif Awduron: Guus H.J. Vorst, Nicole I. Wolf, David R. van Nederpelt, Frederik Barkhof, Marjo S. van der Knaap, Menno M. Schoonheim, Eva M.M. Strijbis, Petra J.W. Pouwels
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2026-01-01
Cyfres:NeuroImage: Clinical
Pynciau:
Skull
Intracranial volume
Neurodegeneration
Multiple sclerosis
Metachromatic leukodystrophy
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S2213158226000276
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