Mutational profile of atypical fibroxanthoma and pleomorphic dermal sarcoma further expands the spectrum of genomic alterations in rare cutaneous neoplasms

Abstract Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare cutaneous mesenchymal tumours sharing clinical and histopathological features. Compared to AFX, PDS has an increased risk of local recurrence and metastasis. A precise diagnosis is critical to ensure proper clinical...

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Autori principali:	Elisabetta Caprini, Giovanni Luca Scaglione, Claudia Scarponi, Martina Morelli, Stefania Madonna, Carla Marani, Valeria Sebastiani, Enrico Scala, Cristina Albanesi, Siavash Rahimi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-05-01
Serie:	Scientific Reports
Soggetti:	Atypical fibroxanthoma Pleomorphic dermal sarcoma Next-generation sequencing NF2 KDR/PDGFRB ATR
Accesso online:	https://doi.org/10.1038/s41598-026-50665-1
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