Evaluation of the Drug–Drug Interaction Potential of the GlyT1 Inhibitor Iclepertin (BI 425809): A Physiologically Based Pharmacokinetic (PBPK) Modeling Approach

ABSTRACT Despite predicting poor functional outcomes and being a significant patient burden, there are no approved pharmacotherapies to treat symptoms of cognitive impairment associated with schizophrenia (CIAS). Iclepertin (BI 425809) is a potent and selective inhibitor of glycine transporter‐1 (Gl...

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Hauptverfasser:	Elin M. Matsson, Michael Desch, Valerie Nock, Nina Hanke
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2025-08-01
Schriftenreihe:	CPT: Pharmacometrics & Systems Pharmacology
Schlagworte:	drug–drug interactions physiology‐based pharmacokinetics schizophrenia
Online-Zugang:	https://doi.org/10.1002/psp4.70060
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