The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.

<h4>Purpose</h4>To examine the in vitro and in vivo efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type colorectal cancer (CRC).<h4>Experimental design</h4>PIK3CA mutant and wild-type human CRC cell lines were treated in vitro with NVP-BEZ235, and the resulting effec...

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Principais autores:	Jatin Roper, Michael P Richardson, Wei Vivian Wang, Larissa Georgeon Richard, Wei Chen, Erin M Coffee, Mark J Sinnamon, Lydia Lee, Peng-Chieh Chen, Roderick T Bronson, Eric S Martin, Kenneth E Hung
Formato:	Artigo
Idioma:	Inglês
Publicado:	Public Library of Science (PLoS) 2011-01-01
Series:	PLoS ONE
Acceso en liña:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0025132&type=printable
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