Topobexin Targets a Unique Druggable Pocket of Topoisomerase II for Beta Isoform- Selective Control of DNA Damage During Anthracycline Chemotherapy

Anthracyclines are potent chemotherapeutic agents, yet their clinical use is hampered by their cardiotoxicity. Anthracyclines achieve potent anti- cancer effects primarily via TOP2A, but at the same time they induce a dose limiting cardiotoxicity through TOP2B. The use of a catalytic TOP2 inhibitors...

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Autors principals:	Jan Kubes, Galina Karabanovich, Anh T. Q. Cong, Iuliia Melnikova, Olga Lencova, Petra Kollarova, Hana Bavlovic Piskackova, Veronika Kerestes, Lenka Applova, Lise C. M. Arrouye, Julia R. Alvey, Jasmina Paluncic, Taylor L. Witter, Anna Jirkovska, Jiri Kunes, Petra Sterbova-Kovarikova, Caroline A. Austin, Martin Sterba, Tomas Simunek, Jaroslav Roh, Matthew J. Schellenberg
Format:	Artigo
Idioma:	Inglês
Publicat:	AIP Publishing LLC and ACA 2025-10-01
Col·lecció:	Structural Dynamics
Accés en línia:	https://pubs.aip.org/aca/sdy/article-pdf/12/5_Supplement/A359/20775525/a359_1_4.0001148.pdf
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