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The Happy Hopping of Transposons: The Origins of V(D)J Recombination in Adaptive Immunity

Nearly 50% of the human genome is derived from transposable elements (TEs). Though dysregulated transposons are deleterious to humans and can lead to diseases, co-opted transposons play an important role in generating alternative or new DNA sequence combinations to perform novel cellular functions....

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Principais autores: Rishi V. Shridharan, Neha Kalakuntla, Narendra Chirmule, Bhavana Tiwari
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-05-01
Serier:Frontiers in Ecology and Evolution
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Online adgang:https://www.frontiersin.org/articles/10.3389/fevo.2022.836066/full
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