Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer’s disease

Abstract Previous studies suggest glial and neuronal changes may trigger synaptic dysfunction in Alzheimer’s disease (AD), but the link between their markers and synaptic abnormalities in the living brain remains unclear. We investigated the association between glial reactivity and synaptic dysfunct...

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Principais autores:	Francieli Rohden, Pamela C. L. Ferreira, Bruna Bellaver, João Pedro Ferrari-Souza, Cristiano S. Aguzzoli, Carolina Soares, Sarah Abbas, Hussein Zalzale, Guilherme Povala, Firoza Z. Lussier, Douglas T. Leffa, Guilherme Bauer-Negrini, Nesrine Rahmouni, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Andrea L. Benedet, Nicholas J. Ashton, Thomas K. Karikari, Dana L. Tudorascu, Henrik Zetterberg, Kaj Blennow, Eduardo R. Zimmer, Diogo Souza, Pedro Rosa-Neto, Tharick A. Pascoal
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-07-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-025-60806-1
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