Probiotic supplementation to mitigate berotralstat gastrointestinal side effects: a multicenter case series from the ITACA network

IntroductionBerotralstat, the first oral plasma kallikrein inhibitor approved for hereditary angioedema (HAE) prophylaxis, may be associated with gastrointestinal (GI) side effects, particularly during the first three months of therapy. Probiotics have been shown to reduce GI disturbances in several...

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Prif Awduron:	Antonio Gidaro, Maria Domenica Guarino, Francesco Arcoleo, Donatella Bignardi, Cristian D’Antonio, Luisa Brussino, Pietro Accardo, Stefania Nicola, Stefano Pucci, Miriam Cognigni, Valentina Popescu Janu, Chiara Cogliati, Emanuele Bizzi, Mauro Cancian
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2026-04-01
Cyfres:	Frontiers in Immunology
Pynciau:	berotralstat gastrointestinal side effects hereditary angioedema ITACA long term prophylaxis microbiome
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1790199/full
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