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Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review

Insulin plays a major neuroprotective and trophic function for cerebral cell population, thus countering apoptosis, beta-amyloid toxicity, and oxidative stress; favoring neuronal survival; and enhancing memory and learning processes. Insulin resistance and impaired cerebral glucose metabolism are in...

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Principais autores: Jorge Berlanga-Acosta, Gerardo Guillén-Nieto, Nadia Rodríguez-Rodríguez, Maria Luisa Bringas-Vega, Diana García-del-Barco-Herrera, Jorge O. Berlanga-Saez, Ariana García-Ojalvo, Mitchell Joseph Valdés-Sosa, Pedro A. Valdés-Sosa
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-11-01
Serier:Frontiers in Endocrinology
Fag:
Alzheimer's disease
neurodegeneration
β-amyloid plaques
neurofibrillary tangles
central insuline resistance
Online adgang:https://www.frontiersin.org/articles/10.3389/fendo.2020.560375/full
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