Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity

Patients with Fabry disease suffer from chronic debilitating pain and peripheral sensory neuropathy with minimal treatment options, but the cellular drivers of this pain are unknown. Here, we propose a mechanism we believe to be novel in which altered signaling between Schwann cells and sensory neur...

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Autori principali: Tyler B. Waltz, Dongman Chao, Eve K. Prodoehl, Jonathan D. Enders, Vanessa L. Ehlers, Bhavya S. Dharanikota, Nancy M. Dahms, Elena Isaeva, Quinn H. Hogan, Bin Pan, Cheryl L. Stucky
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical investigation 2024-04-01
Serie:JCI Insight
Soggetti:
Neuroscience
Accesso online:https://doi.org/10.1172/jci.insight.172869
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