Targeted management of coexistent severe thrombophilias—A case report of a successful pregnancy despite paroxysmal nocturnal hemoglobinuria and hereditary protein C deficiency

Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by the absence of complement regulatory proteins on the surface of erythrocytes, leading to intravascular hemolysis and thrombosis. Managing PNH during pregnancy poses significant challenges due to incr...

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Principais autores:	Julien Dereme, Matthew Goodyer, David Baud, Lorenzo Alberio, Francesco Grandoni, Mathilde Gavillet
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2024-10-01
Series:	eJHaem
Assuntos:	anticoagulation breakthrough hemolysis C5‐inhibitor complement activation complement inhibitor eculizumab
Acceso en liña:	https://doi.org/10.1002/jha2.972
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