MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques.

In complement to an effective vaccine, development of potent anti-HIV microbicides remains an important priority. We have previously shown that the miniCD4 M48U1, a functional mimetic of sCD4 presented on a 27 amino-acid stable scaffold, inhibits a broad range of HIV-1 isolates at sub-nanomolar conc...

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Principais autores:	Nathalie Dereuddre-Bosquet, Laurence Morellato-Castillo, Joachim Brouwers, Patrick Augustijns, Kawthar Bouchemal, Gilles Ponchel, Oscar H P Ramos, Carolina Herrera, Martha Stefanidou, Robin Shattock, Leo Heyndrickx, Guido Vanham, Pascal Kessler, Roger Le Grand, Loïc Martin
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2012-01-01
Serija:	PLoS Pathogens
Online dostop:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003071&type=printable
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