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Systematic analysis of cilia characteristics and Hedgehog signaling in five immortal cell lines.

Dysfunction of the primary cilium, a microtubule-based signaling organelle, leads to genetic conditions called ciliopathies. Hedgehog (Hh) signaling is mediated by the primary cilium in vertebrates and is therefore implicated in ciliopathies; however, it is not clear which immortal cell lines are th...

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Hlavní autoři: Arianna Ericka Gómez, Angela K Christman, Julie Craft Van De Weghe, Malaney Finn, Dan Doherty
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2022-01-01
Edice:PLoS ONE
On-line přístup:https://doi.org/10.1371/journal.pone.0266433
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