Reno-protective effect of mangiferin against methotrexate-induced kidney damage in male rats: PPARγ-mediated antioxidant activity

Methotrexate (MTX) is an immunosuppressant used for the treatment of cancer and autoimmune diseases. MTX has a major adverse effect, acute kidney injury, which limits its use. Mangiferin (MF) is a natural bioactive xanthonoid used as a traditional herbal supplement to boost the immune system due to...

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Bibliografische Detailangaben

Hauptverfasser:	Seba Hassan Attia, Shimaa Mustafa Elshazly, Mahmoud Mohamed Abdelaal, Eman Soliman
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer 2022-09-01
Schriftenreihe:	Saudi Pharmaceutical Journal
Schlagworte:	Mangiferin Methotrexate Nephrotoxicity Peroxisome proliferator-activated receptor-γ (PPAR-γ) Oxidative stress
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S1319016422001839
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