Differential regulation of Treg stability in human naïve and effector Treg subsets by TGFβ-signaling via ARKADIA-SKI axis

IntroductionThe human FOXP3+ regulatory T (Treg) cells, a subset of CD4+ T cells with immunosuppressive function, are essential for the maintenance of immune homeostasis and tolerance. Treg cells are a heterogeneous population, subdivided into a less stable “effector” subset and a more stable “naïve...

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Bibliografische Detailangaben

Hauptverfasser:	Fan Yang, Alexis Yanes, Miao Li, Patrick Heizer, Ivan Linatoc, Michael E. Stephens, Yang Song, Tatiana Ort, Kyle J. Bednar, Yasuhiro Ikeda, Zengli Guo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-09-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	Treg TGFβ autoimmune naïve/effector Treg cell Ski Arkadia
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1636434/full
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