αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
Interaction of fibronectin with αv-class and α5β1 integrins results in formation of cell adhesion complexes, but the initial events (<120 s) remain unclear. Here, the authors show that αv-class integrins bind fibronectin faster than α5β1 integrins and subsequently signal to α5ß1 integrins to strengt...
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| Principais autores: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2017-01-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/ncomms14348 |
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