SpaNiche: spatial niche analysis to explore colocalization patterns and cellular interactions in spatial transcriptomics data
Abstract We propose a computational framework for spatial niche analysis (SpaNiche) in spatial transcriptomics data to uncover colocalization patterns and infer potential ligand-receptor interactions. SpaNiche leverages graph-regularized joint non-negative matrix factorization to integrate informati...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BMC
2026-04-01
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| Colección: | Genome Biology |
| Acceso en línea: | https://doi.org/10.1186/s13059-026-04069-z |
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