Flurbiprofen inhibits heme induced NLRP3 inflammasome in Berkeley sickle cell disease mice

Sickle cell disease (SCD) is accompanied by several complications, which emanate from the sickling of erythrocytes due to a point mutation in the β-globin chain of hemoglobin. Sickled erythrocytes are unable to move smoothly through small blood capillaries and therefore, cause vaso occlusion and sev...

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Главные авторы:	Dilpreet Kour, Mehboob Ali, Parul Khajuria, Kuhu Sharma, Palash Ghosh, Sukhleen Kaur, Surbhi Mahajan, P. Ramajayan, Sonali S. Bharate, Subhash Bhardwaj, Sanghapal D. Sawant, D. Srinivasa Reddy, Ajay Kumar
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2023-04-01
Серии:	Frontiers in Pharmacology
Предметы:	sickle cell disease flurbiprofen NLRP3 inflammasome inflammation pain Berkeley mice
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1123734/full
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