Interaction between human leukocyte antigen (HLA-C) and killer cell Ig-like receptors (KIR2DL) inhibits the cytotoxicity of natural killer cells in patients with hepatoblastoma

BackgroundHepatoblastoma (HB) is the most common liver malignancy in childhood with poor prognosis and lack of effective therapeutic targets. Single-cell transcriptome sequencing technology has been widely used in the study of malignant tumors, which can understand the tumor microenvironment and tum...

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Principais autores:	Jing-Jie Guo, Yong-Qin Ye, Yi-Di Liu, Wei-Fang Wu, Qian-Qian Mei, Xi-Yun Zhang, Jing Lao, Bin Wang, Jian-Yao Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-11-01
Colecção:	Frontiers in Medicine
Assuntos:	hepatoblastoma single-cell transcriptome sequencing PBMC NK cells KIR2DL
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmed.2022.947729/full
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